Jamie Cate Wiki – Jamie Cate Biography
Jamie Cate is the husband of Jennifer Doudna He is also Professor of Chemistry, Biochemistry and Molecular Biology
Jamie Cate Relationship with Jennifer Doudna
As a postdoctoral student at the University of Colorado Doudna met Jamie Cate, then a graduate student; they worked together on the project to crystallize and determine the structure of the Tetrahymena Group I intron P4-P6 catalytic region.
They married when she was teaching at Yale, and they both accepted faculty positions at UC Berkeley and moved there. He is currently a UC Berkeley professor and works on gene-editing yeast to increase their cellulose fermentation for biofuel production. Their son (born 2003) “likes computers and math”
Jamie Cate research at genetic code
Dr Jamie Cate has had a long-time interest in understanding how the ribosome translates the genetic code into proteins. A primary focus in his laboratory is the study of human translation, focusing on the role of the human translation initiation factor eIF3 and on ribosome blocking mechanisms.
Using biochemical and structural biology, his laboratory has revealed the fundamental mechanisms of the initiation of human translation, including the discovery of a 5′-m7G mRNA cap-binding activity in the regulation of specific mRNAs mediated by human eIF3 and eIF3. . In collaboration with Pfizer, his laboratory also revealed a new molecular mechanism of action for small molecules that can selectively stop protein synthesis on the ribosome.
Jamie Cate Ph.D
Jamie Cate received his Ph.D. from the Department of Molecular Biophysics and Biochemistry at Yale University. Following a postdoctoral fellowship from the Damon Runyon-Walter Winchell Cancer Research Fund at the University of California, Santa Cruz, he joined the MIT faculty as an associate member of the Whitehead Institute for Biomedical Research.
He is now a professor of biochemistry, biophysics, and structural biology at the University of California, Berkeley. His research has been recognized with the Searle Scholar Award, the AAAS Newcomb Cleveland Award, and the Irving Sigal Young Investigator Award from The Protein Society. He is also a member of the American Academy of Arts and Sciences.
Jamie Cate Research Interests
Protein Synthesis Understanding how the ribosome makes proteins and how these proteins fold remains a major challenge in biology. The lab is interested in how the ribosome initiates protein synthesis in humans, a highly-regulated step important for human health. The lab is also exploring proteins as they emerge from the ribosome, and how they are targeted to their final destination. Using bacterial translation, we are exploring ways to engineer the ribosome to make polymers other than proteins.
To determine the mechanisms underlying protein synthesis and its regulation, the lab uses a combination of cryo-electron microscopy, systems biology, biochemistry and biophysics.
Jamie Cate Voracious Yeast Project
Perennial plants fix vast quantities of carbon dioxide into sugars in the plant cell wall. These sugars could serve as an abundant source for producing biofuels and renewable chemicals, but extracting them for conversion remains an unsolved problem. We are using a combination of systems biology, mechanistic enzymology, and synthetic biology to engineer a “Voracious Yeast” for biofuel and renewable chemical production from plants.